Journal
Molecular Imaging and Biology
Molecular Imaging and Biology focuses on the utilization of molecular imaging in understanding biology and medicine.
Electron paramagnetic resonance imaging (EPRI or eMRI) detects the magnetization of unpaired electron spins in exogenous contrast agents. Similar to magnetic resonance imaging (MRI), EPRI uses a static magnetic field, magnetic field gradients, and radio-frequency energy pulses to generate spatial images. In contrast to MRI, EPRI uses much smaller magnetic fields because of the higher gyromagnetic ratio of electrons compared to water protons. EPRI uses an exogenous contrast agent sensitive to the parameter of interest. The leading application of EPRI is in determining partial oxygen pressure (pO2) in tissues, while other applications, such as pH and redox imaging, are also catching up. Together, these biomarkers of the tissue microenvironment can provide insights into pathologies and support modern complex treatment strategies in cancer, type I diabetes, and many other medical fields. To accelerate the dissemination of the latest research in the field, we invite the submission of research reports that focus on biological and biomedical applications, clinical translation, and the chemistry of new agents for EPR imaging.
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Dr. Mrignayani Kotecha
Dr. Mrignayani Kotecha is the President and CEO of Chicago-based biotech company O2M Technologies, LLC (https://oxygenimaging.com). In this role, she leads the development of the world’s first preclinical and clinical electron paramagnetic resonance oxygen imagers for biomedical research and clinical applications in oncology, spin-probe synthesis, fundraising, and outreach activities. She also leads the “Oxygen Measurement Core” research facility at O2M, which collaborates with academic, government, and industry members to perform cutting-edge research. -
Dr. Mark David Pagel
The University of Texas MD Anderson Cancer Center, Houston, Texas, United States. Dr. Mark “Marty” Pagel directs the Contrast Agent Molecular Engineering Laboratory (CAMEL). His research focuses on molecular imaging at the pre-clinical and clinical levels using EPR imaging, MRI, PET/MRI and photoacoustic imaging. His cancer imaging studies interrogate biomarkers of the tumor microenvironment.
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